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Casualties Unknown infection and radiation guide

A character on a brick ledge in a green glowing radioactive cave, saying I want to eat
A green radioactive layer. Radiation builds up with exposure and close contact. Official Steam screenshot, © Orsoniks / Oro Interactive.

Short answer: infections in Casualties Unknown start in wounds with low skin health and spread faster when you are dirty. Keep cleaning, and apply a disinfectant such as glow fruit or a sterilized dressing to the infected limb. Radiation builds up from toxirock, spent fuel and the rising radiation line, and anti-rad treats it. confirmed

An infection is one of the slowest ways to die, which is why people ignore it. One beginner guide warns that a rampant infection will be a run-ender. confirmed

How do you get an infection in Casualties Unknown?

Infections usually begin when cuts or other injuries damage a limb’s skin health, shown as a shield icon at the bottom left of the panel. confirmed Two things make them worse.

  • Dirt. A dirty body makes infections more likely and speeds them up. confirmed
  • Sleeping on a weak limb. Going to sleep with low skin health can infect wounds, instead of healing them. confirmed

Infections have been visible even when unchipped since 6.0, so you will still see them if you play with numbers hidden. confirmed

How do you treat an infection?

Apply disinfectant by dragging it onto the infected body part in the health panel. It reverses the infection until it is gone, as long as you keep applying it. confirmed

Treatment Notes Status
Glow fruit Easy early option, but it damages the limb’s skin health confirmed
Sterilized dressing Lasts a long time; a good early investment confirmed
Antiseptic Stronger, harder to craft confirmed
Antiseptic mush Crafted; buffed in 7.0, can be put in medkits confirmed
Antibiotics Medicine from loot and traders confirmed

The glow fruit downside matters. It hurts the skin health that protects you from infection in the first place, so overusing it can make things worse. confirmed One popular guide’s advice is to make sterilized dressings instead: 400 ml of soap and one regular dressing make one, and even a small amount disinfects a limb for a long while. confirmed

Soap uses meat, the ingredients for a campfire, chem fuel and water. confirmed

How do you stay clean in Casualties Unknown?

Wash by submerging yourself in water. In shallow water, hold X to ragdoll yourself and keep moving until the dirt stops coming off. confirmed Oil, on the other hand, makes you instantly dirty, so avoid it. confirmed You can also wipe yourself with the rag item, added in 6.0. confirmed

Bathing costs time and can leave you cold and wet, so do it when you are warm and safe. See food, water and sleep for how temperature works.

What is sepsis?

Sepsis is the worst stage of a spreading infection. Recordings show players reacting to it urgently, because at that point a run can end quickly. confirmed Patch 6.1 reduced how much it affects blood pressure. confirmed

If an infection has spread beyond what your supplies can handle, removing the limb may be the only way to stop it. A recording shows a player preparing to cut off a foot that is “getting worse and worse by the second”. confirmed The limb guide covers amputation.

How does radiation work in Casualties Unknown?

Radiation builds up from exposure. The panel shows it as a value in Gy, and the official health panel screenshot displays 0.0 Gy under a radiation symbol. confirmed Main sources:

Source How it works Status
Toxirock Builds up on direct contact confirmed
Spent fuel barrels Builds up with proximity; barrels are almost indestructible confirmed
Radiation line Rising band that punishes staying too long confirmed
Ionized layer modifier Nuclear waste dumped through the layer confirmed
Radioactive water Reported by players; avoid drinking it reported

The wasteland, layer 4, is built around this. Keep your distance from barrels and dig around them rather than through. confirmed

How do you treat radiation in Casualties Unknown?

Anti-rad is the standard treatment, and an Ionized layer now spawns some near the waste. confirmed Do not overuse it: since 6.0 you can overdose on anti-rad, with a moodle added in 6.1 that shows when you are overdosing. confirmed

A craftable geiger counter, added in 7.0, tells you what is around you before you walk into it. confirmed A new visual for severe radiation sickness arrived in 6.0, so sudden visual changes on a radioactive layer are worth taking seriously. confirmed

What is toxicosis and sickness?

Sickness is a separate bar from infection. It comes from bad food and drink. As long as the moodle stays at “queasy”, around 25%, you will be fine, which is why people eat rough food when they have to. confirmed Going further makes you vomit. Vomiting blood slows you down less than it did before 7.0. confirmed

What should you carry for infection and radiation?

Sterilized dressings, antiseptic if you can make it, and at least one dose of anti-rad before layer 4. Keep your mood high too, because hard runs tend to fail when you are already low and something new goes wrong.

Sources

Last checked 9 November 2026. Marks: confirmed = official notes, in-game text or a recording of the game; reported = two or more players; unverified = one source.

  1. Beginners Guide: Injury and Treatment by Cain · infection basics
  2. 30 Things Everyone Should Know by BluePawClaw · skin health, glowfruit
  3. Tricks I Wish I Knew Sooner by BluePawClaw · sterilized dressings
  4. In-Depth Guide: Traps and Hazards by Cameron Kane · toxirock, spent fuel
  5. v6.0 Patch Notes, Steam
  6. 6.1 Demo Patch Notes, Steam